The Neuroscience Lead (or CNS) will manage the CNS functional group within the Discovery Research group under Translational Research. He/she will be responsible for:
• Providing leadership within a group of scientists/research associates, to develop pre-clinical programs from early discovery to the clinic
• Initiate and oversee joint programs with academic collaborators.
• Establishing project timelines and ensuring work is completed according to schedule.
• Training and developing staff at varying levels of experience.
The CNS Preclinicnal Lead position requires extensive translational experience with CNS gene therapies, including;
• In-depth knowledge of neurodegenerative disorders.
• Experience with delivery techniques targeting the central nervous system such as intracranial injecions and have substantial experience with studies in laboratory animals.
• Familiarity with target validation and lead identification/optimization, using a combination of molecular, cellular and in vitro/in vivo techniques for CNS gene therapy programs.
• Some familiarity with AAV, as well as some knowledge of clinical trial design and regulatory strategy, is preferred.
20% Hands-on execution of experiments on the bench
40% Identify and validate new indication targets. Design and trouble-shoot experiments based on personal experience and literature review. Prepare and deliver scientific presentations at internal and external meetings
20% Prioritize projects, plan workload, manage resource and personnel scheduling
10% Preparing sample analysis reports and write parts of regulatory submissions to FDA
10% Lead a team of scientists. Mentor and develop staff.
Ensure departmental goals and objectives are met and aligned to the broader organizational goals and objectives.
• Extensive hands-on experience in CNS/neurodegenerative disease models and manipulations, such as intracerebroventricular and intraparenchymal injections, with experience in CNS gene therapy preferred.
• Strong organizational skills.
• Excellent writing and verbal communication skills.
• Previous management experience preferred, but not required.
• Strong publication record is a plus.
• Experience with AAV vectors is a plus.
• Demonstrate independent problem solving skills of technical issues; develop solutions to a variety of moderate to complex problems. Discuss with supervisor and refer to policies/practices for guidance.
• Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
• Exercise judgment within defined procedures and practices to determine appropriate action.
• Ph.D. in relevant scientific discipline (e.g. cell and molecular biology, biochemistry, etc.)
• Minimum 5-8 years of hands-on experience in the field of gene therapy for neurodegenerative disorders.
• Previous management or supervisory experience strongly preferred.
WHO WE ARE:
Transforming Patient’s Lives. Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.