2017-12-13

Ocular Pre-Clinical Research Lead
Job Opportunity at Spark Therapeutics, Inc

Posted on Dec 13

http://www.sparktx.com    215-220-9300

Location: Philadelphia, PA
Job Type: Full Time
Job ID: W4142249

The Ocular Pre-Clinical Research Lead will manage the Ocular functional group within the Research department. He/she will be responsible for:

• Providing leadership within a group of 2 to 3 scientists/research associates, to develop pre-clinical programs from early discovery to the clinic.

• Initiate and oversee joint programs with academic collaborators. 

• Establishing project timelines and ensuring work is completed according to schedule.

• Training and developing staff at varying levels of experience.

The Ocular Pre-Clinical Research Lead position requires extensive translational experience with ocular gene therapies, including:

• In-depth knowledge of inherited retinal disorders is required. 

• Experience with animal models of inherited retinal disorders and use of AAV gene therapy to treat these disorders is required.

• Experience with functional and structural endpoint measurements, such as ERG, optokinetic analysis, imaging, etc.

• Experience with intraocular delivery techniques

• Familiarity with target validation and lead identification/optimization, using a combination of molecular, cellular and in vitro/in vivo techniques for ophthalmic gene therapy. 

• Some knowledge of clinical trial design and regulatory strategy is preferred. 

RESPONSIBILITIES:

20%    Hands-on execution of experiments on the bench

50%    Identify and validate new indication targets. Design and trouble-shoot experiments based on personal experience and literature review. Prepare and deliver scientific presentations at internal and external meetings

10%    Prioritize projects, plan workload, manage resource and personnel scheduling

10%    Preparing sample analysis reports and write parts of regulatory submissions to FDA

10%    Lead a team of scientists.  Mentor and develop staff.


•    Identify and validate new indication targets. Design and trouble-shoot experiments based on personal experience and literature review. Prepare and deliver scientific presentations at internal and external meetings

•    Prioritize projects, plan workload, manage resource and personnel scheduling

•    Preparing sample analysis reports and write parts of regulatory submissions to FDA

•    Lead a team of scientists.  Mentor and develop staff.

•    Ensure departmental goals and objectives are met and aligned to the broader organizational goals and objectives.

QUALIFICATIONS:

•    Extensive hands-on experience in ocular gene therapy, such as intravitreal and subretinal injections, and measurement of ophthalmic efficacy and safety endpoints

•    Strong organizational skills.

•    Excellent writing and verbal communication skills.

•    Previous management experience preferred, but not required.

•    Strong publication record is a plus.

•    Experience with AAV vectors is a plus.

•    Demonstrate independent problem solving skills of technical issues; develop solutions to a variety of moderate to complex problems; Discuss with supervisor and refer to policies/practices for guidance.

•    Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark

•    Exercise judgment within defined procedures and practices to determine appropriate action.

•    Quality Assurance, Clinical Operations, Pharm/Tox, Discovery, Assay Development, R&D Operations, Technical Operations, Regulatory Affairs, Executive Team.


REQUIREMENTS:

•    Ph.D. in relevant scientific discipline (e.g. cell and molecular biology, biochemistry, etc.) 

•    Minimum 5-8 years of hands-on experience in the field of ophthalmic gene therapy 

•    Previous management or supervisory experience strongly preferred



WHO WE ARE:

Transforming Patient’s Lives. Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.













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