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PD Scientist - Analytical
Job Opportunity at
Spark Therapeutics, Inc
Posted on Dec 2
The Process Development Scientist is a key role in the Process Development Analytical team. He/she will function as an Analytical Scientist to develop and implement new assays, optimize existing assays based on in-depth knowledge of laboratory techniques and perform analytical experiments to support upstream and downstream process development at Spark.
The major responsibilities are as follows, but not limited to:
Conduct analytical experiments to support process development of Upstream, Downstream and Pre-Clinical Operation teams
Design and perform analytical experiments to determine rAAV yield and recovery, vector purity and potency while delivering reliable high-quality experimental data and preparing experimental reports in a timely manner
Provide analytical expertise to troubleshoot issues and resolve the issues timely
Develop and implement new analytical methods or optimize existing methods with limit guidance from supervisor and other team members to support rAAV production and purification methods
Work closely with team members to ensure the availability of adequate laboratory materials as needed
Execute routine lab operations on an ongoing basis, maintain accurate, timely and detailed records of work
Collaborate with facility for instrument maintenance and calibration
Working in the labs to perform experiments described above in the job primary duties
Design experiments, organize, discuss and record experimental data.
Prepare presenting materials, literature search and so on.
Trainings, lab meetings and administration work
Strong analytical skills and problem-solving capabilities; familiar with variety of lab techniques, including PCR, Q-PCR, digital PCR, Protein assays, ELISA-based assays and cell-based assays.
Proven ability to work independently in hands-on laboratory setting, self-motivated to learn and develop new techniques
Capable of performing multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies. Good personal communication skills and team worker.
Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
Knowledge of gene therapy is preferred, but not required.
Ph.D in biological sciences required
Minimum of two years of relevant working with analytical technologies in pharma/biotech industry experience
Experience with viral vector production, Q-PCR, digital PCR, ELISA-based assays and cell-based assay is preferred
WHO WE ARE:
Transforming Patient’s Lives. Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.
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