2017-12-02

PD Scientist - Analytical
Job Opportunity at Spark Therapeutics, Inc

Posted on Dec 2

http://www.sparktx.com    215-220-9300

Location: Philadelphia, PA
Job Type: Full Time
Job ID: W4145686

The Process Development Scientist is a key role in the Process Development Analytical team. He/she will function as an Analytical Scientist to develop and implement new assays, optimize existing assays based on in-depth knowledge of laboratory techniques and perform analytical experiments to support upstream and downstream process development at Spark. 
 
  • The major responsibilities are as follows, but not limited to:
  • Conduct analytical experiments to support process development of Upstream, Downstream and Pre-Clinical Operation teams
  • Design and perform analytical experiments to determine rAAV yield and recovery, vector purity and potency while delivering reliable high-quality experimental data and preparing experimental reports in a timely manner
  • Provide analytical expertise to troubleshoot issues and resolve the issues timely
  • Develop and implement new analytical methods or optimize existing methods with limit guidance from supervisor and other team members to support rAAV production and purification methods      
  • Work closely with team members to ensure the availability of adequate laboratory materials as needed 
  • Execute routine lab operations on an ongoing basis, maintain accurate, timely and detailed records of work
  • Collaborate with facility for instrument maintenance and calibration

RESPONBILITIES:
75%      
  • Working in the labs to perform experiments described above in the job primary duties
15%      
  • Design experiments, organize, discuss and record experimental data.
5%        
  • Prepare presenting materials, literature search and so on.   
5%        
  • Trainings, lab meetings and administration work

QUALIFICATIONS:
  • Strong analytical skills and problem-solving capabilities; familiar with variety of lab techniques, including PCR, Q-PCR, digital PCR, Protein assays, ELISA-based assays and cell-based assays.
  • Proven ability to work independently in hands-on laboratory setting, self-motivated to learn and develop new techniques
  • Capable of performing multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies.  Good personal communication skills and team worker.
  • Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
  • Knowledge of gene therapy is preferred, but not required.

REQUIREMENTS:
  • Ph.D in biological sciences required
  • Minimum of two years of relevant working with analytical technologies in pharma/biotech industry experience
  • Experience with viral vector production, Q-PCR, digital PCR, ELISA-based assays and cell-based assay is preferred

WHO WE ARE:

Transforming Patient’s Lives. Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.




















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