Translational Research, Laboratory Manager
Job Opportunity at Spark Therapeutics, Inc

Posted on Jun 21    215-220-9300

Location: Philadelphia, PA
Job Type: Full Time
Job ID: W4111017

Manage the day to day technical operation of the translational lab, inclusive of:  assay development, pharmacology & toxicology, and discovery research. 
  • Champion all safety aspects in the Translational Laboratories. 
  • Implement and manage an inventory system for biological reagents (plasmids, cells, vectors) and co-ordinate reception and shipment of reagents.
  • Train and assist technical staff in the performance of laboratory experiments ensuring work is completed according to project time lines.
  • Responsible for short and long term planning for all aspects of lab operations, maintaining focus on scientific goals of the pipe line programs. 
  • Oversee and manage the day-to-day operations of our external vivarium vendor.
  • Ensuring adequate personnel, space, equipment, and facilities remain available.
  • Coordinate the work load in collaboration with other department leads. 
  • Independently design, determine techniques and perform experiments on the bench.  
  • Mentor and develop staff. Train and assist technical staff in the performance of laboratory experiments.  Responsible for all safety aspects and best practices, and employee training. 
  • Ensure departmental goals and objectives are met and aligned to the broader organizational goals and objectives.
  • Prioritize and plan projects and workloads, manage resources and personnel scheduling. 
  • Coordinate and align centralized lab management efforts across assay development, pharmacology, toxicology and discovery research.   
  • Short and long term planning of lab operations
  • Oversee and manage the day-to-day operations of our external vivarium vendor
  • Implement and maintain Spark Translational inventory system
  • Supplier & Vendor Management and negotiations
  • Manage translational research samples and materials
    • Bachelor’s degree required; PhD in a relevant field preferred.
    • Minimum of 5-8 years of strategic and hands-on laboratory experience. 
    • Previous management or supervisory experience strongly preferred.
    • Broad understanding of the technical and equipment needs in a lab as well as extensive hands-on experience with standard molecular and cell biology techniques such as DNA cloning, qPCR, ELISA, flow cytometry, cell culture, etc.
    • Experience with AAV vectors is a plus.
    • Strong organizational skills.
    • Excellent writing and verbal communication skills.
    • Demonstrated ability to effectively manage performance and talent.
    • Demonstrate independent problem solving skills of technical issues; develop solutions to a variety of moderate to complex problems; Discuss with supervisor and refer to policies/practices for guidance.
    • Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
    • Exercise judgment within defined procedures and practices to determine appropriate action.
    • Quality Assurance, Clinical Operations, Pharm/Tox, Discovery, Assay Validation, R&D Operations, Technical Operations, Regulatory Affairs

    Transforming Patient’s Lives. 
    Spark Therapeutics is a pioneering gene therapy leader transforming the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. We are embarking on our goal to deliver the first approved gene therapy product in the US for genetic blinding conditions and have a product pipeline addressing other unmet rare genetic diseases. We have an entrepreneurial culture and are looking for talented and passionate professionals who are committed and motivated to making a difference in the lives of our patients. If you share our passion for excellence and are looking for a dynamic work environment that fosters creativity, scientific innovation and team collaboration, you may be a great fit for our team.

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